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University of Helsinki - Institute of Biotechnology




The Light microscopy unit of the Institute of Biotechnology serves primarily researchers at the University of Helsinki but also commercial users. LMU is member of Helsinki Functional Imaging Center and European Light Microscopy Initiative.


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[Biochemistry and Molecular Biology] A Comprehensive Clinical and Biochemical Functional Study of a Novel RPE65 Hypomorphic Mutation

This paper is a comprehensive analysis of an Rpe65 mutation associated with an extremely mild phenotype in early childhood, and correlates this phenotype with the low level isomerase activity of a severely hypomorphic RPE65 mutant protein.

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Alchemist's Gold: The Remarkable One-Dimensional Hg Chain Compound
Alan Heeger (Nobel Laureate, Santa Barbara)
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Fruit fly discovery generates buzz about brain-damaging disorder in children
(Johns Hopkins Medical Institutions) Johns Hopkins researchers have used fruit flies to gain new insights into a brain-damaging disorder afflicting children. Their work suggests a possible therapy for the disease, for which there is currently no treatment.
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Study of the Effects of a Chayotte (Sechium edule) Extract on the Plasmid Puc. 9.1 Dna
Stannous chloride (SnCl2) is employed as a reducing agent to obtain Technetium-99m-labelled radiopharmaceuticals in nuclear medicine kits, being inject endogenously in humans. Toxic effects of. these kits were not studied, thus making it important to evaluate their impact in humans. The use of natural extracts as medicines is growing around the world. The chayotte (Sechium edule) is a subtropical vegetable with potent diuretic action. It is used in folk medicine due its hypotensor effect. In this study, plasmid deoxyribonucleic acid (DNA) was exposed to chayotte extracts (macerated) (0.1g mL-1) in presence of stannous chloride (SnCl2). Samples of the plasmid DNA were analyzed through agarose gel electrophoresis. The results show that the chayotte extract was capable of damaging the DNA in the presence and in the absent of SnCl2.
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